Neuroleptic Malignant Syndrome : Report of 2 Cases

Neuroleptic malignant syndrome (NMS) is one of the rave but potentially fatal, idiosyncratic reaction to Neuroleptics and other medications (Smego and Durack, 1985). I t is characterised by fever, autonomic dysfunction, rigidity, altered conscious state with associated laboratory parameters like raised GPK, LDH, Hepatic enzymes, leucocytosis. This syndrome was first described by Delay and Deniker in 1968. Since 1980 about 50 cases have appeared in British and French literature (Coonset al, 1982; Goekoop and Garbaat , 1982). A psychiatrist must be aware of this syndrome wich may be many times under diagnosed. Recently we have successfully treated two cases of Neuroleptic Malignant Syndrome.